Ian Loftus: Publications

1) Loftus IM, London NJM, Thirdborough SM, Bell PRF, James RFL.
Isogeneic Islet Transplantation - The Effect of Gamma Irradiation.
Transplantation 1991: 52(3); 567.

2) London NJM, Thirdborough SM, Loftus IM, Bell PRF, James RFL.
Renal Subcapsular Islet Transplantation in the Rat, a Comparison of 3 Techniques. Diabetes Research 1991: 16; 81.

3) Loftus IM, Ubhi SS, Watkin DFL. Case Report, Minerva.
British Medical Journal 1995: 311; 1238.

4) Loftus IM, Baker D, Fossard DP.
Delayed Presentation of Diaphragm Rupture.
Hospital Update 1996: 22(6); 254.

5) Loftus IM, Kocklebergh RC, Flynn JT.
A Reno-colic Fistula Associated with Adult Polycystic Kidney Disease.
British Journal of Urology 1996: 78; 473-4.

6) Loftus IM, Ubhi SS, Watkin DF.
Herniography for groin pain of uncertain origin.
British Journal of Surgery 1997: 84; 684-5.

7) Loftus IM, Thompson MM, Fishwick G, Bell PRF, London NJM.
A technique for rapid control of bleeding from an aorto-enteric fistula.
British Journal of Surgery 1997: 84; 1114.

8) Loftus IM, Watkin DFL.
The Provision of a Day Case Abscess Service.
Annals of The Royal College of Surgeons of England 1997: 79; 289-90.

9) Loftus IM, Ubhi SS, P Rodgers, Watkin DFL.
A negative herniogram does not exclude the presence of a hernia.
Annals of The Royal College of Surgeons of England 1997: 79; 372-5.

10) Loftus IM, Reid A, Thompson MM, London NJM, Bell PRF, Naylor AR.
The increasing workload required to maintain infrainguinal bypass graft patency.
European Journal of Vascular and Endovascular Surgery 1998: 15(4); 337-341.

11) Boyle JR, Loftus IM, Goodall S, Crowther M, Wills A, Bell PRF, Thompson
MM.
Amlodipine potentiates metalloproteinase activity and accelerates elastin
degradation in a model of aneurysmal disease.
European Journal of Vascular and Endovascular Surgery 1998; 16(5): 408-414.

12) Loftus IM, McCarthy MC, Pau H, London NJM, Bell PRF, Naylor ARN.
Carotid endarterectomy without angiography does not compromise operative outcome.
European Journal of Vascular and Endovascular Surgery 1998; 16(6): 489-493.

13) Porter K, Loftus IM, Peterson M, Bell PRF, London NJM, Thompson MM.
Marimastat inhibits neointimal thickening in a model of human vein graft stenosis.
British Journal of Surgery 1998; 85:1373-1377.

14) Loftus IM, Boyle JR, Fishwick G, Thompson MM and Bell PRF.
Endovascular Repair for Aortic Aneurysm in the Presence of a Horseshoe Kidney.
Journal of Endovascular Surgery 1998; 5: 278-281.

15) McCarthy MJ, Olojugba D, Loftus IM, Naylor AR, Bell PRF, London NJM.
Lower limb surveillance following autologous vein bypass should be life long.
British Journal of Surgery 1998; 85: 1369-1372.

16) Loftus IM, McCarthy MJ, Lloyd A, AR Naylor, Bell PRF and Thompson MM.
Prevalence of True Vein Graft Aneurysms - Implications for Aneurysm Pathogenesis.
Journal of Vascular Surgery 1999; 29(3): 403-408.

17) Porter K, Thompson MM, Loftus IM, Jones L, Crowther M, Bell PRF, LondonNJM.
The production and inhibition of the gelatinolytic matrix metalloproteinases in a human model of vein graft stenosis.
European Journal of Vascular and Endovascular Surgery 1999; 17: 404.

18) Thompson MM, Boyle JR, Crowther M, Goodall S, Loftus IM, Bell PRF.
Therapeutic options in small abdominal aneurysms.
Annals of the New York Academy of Science 1999; 878: 724-7.

19) Loftus IM, Porter K, Peterson M, Bell PRF, London NJM, Thompson MM.
MMP inhibition reduces intimal hyperplasia in a human vein graft stenosis model.
Annals of the New York Academy of Science 1999;878:547-50.

20) Loftus IM, Naylor AR, Goodall S, Jones L, Bell PRF, Thompson MM.
Increased carotid plaque MMP9 activity: pharmacotherapy to prevent stroke.
Annals of the New York Academy of Science 1999; 878: 551-4.

21) Treharne G, Loftus IM, Lennard N, Smith J, Fishwick G, Thompson MM, Bell
PRF.
Quality control during endovascular aneurysm repair.
Journal of Endovascular Surgery 1999; 6(3): 239-245.

22) Loftus IM, Thompson MM, Fishwick G, Boyle J and Bell PRF.
Aortic Aneurysms In The Presence Of A Horseshoe Kidney Treated By Endovascular Repair.
Urology Review 1999: 4; 14-15.

23) Loftus IM, Naylor AR, Goodall S, Crowther M, Jones L, Bell PRF, ThompsonMM.
Increased MMP-9 Activity in Unstable Carotid Plaques- A Potential Role in Acute Plaque Disruption.
Stroke 2000; 31: 40-47.

24) McCarthy MJ, Loftus IM, Thompson MM, Jones L, London NJM, Bell PRF,Naylor AR, Brindle NPJ.
Angiogenesis and the atherosclerotic carotid plaque: an association
between symptomatology and plaque morphology.
Journal of Vascular Surgery 1999; 30: 261-8.

25) Treharne GD, Boyle JR, Goodall S, Loftus IM, Bell PRF, Thompson MM.
Marimastat inhibits elastin degradation and matrix metalloproteinase 2 activity in a model of aneurysmal disease.
British Journal of Surgery 1999; 86: 1053-8.

26) Peterson M, Porter K, Loftus IM, Thompson MM, London N.
Marimastat inhibits neointimal thickening in a model of human arterial intimal hyperplasia.
European Journal of Vascular and Endovascular Surgery 2000; 19: 461-467.

27) Sensier YJ, Thrush AJ, Loftus IM, Evans DH, London NJM.
A comparison of colour duplex ultrasonography, papaverine testing and common femoral doppler waveform analysis for assessment of the aortoiliac arteries.
European Journal of Vascular and Endovascular Surgery 2000; 20: 29-35.

28) Loftus IM. Preoperative staging of rectal cancer allows selection of patients for
preoperative radiotherapy.
British Journal of Surgery 2001; 87: 1733

29) Axisa BM, Loftus IM, Fishwick G, Spyt T, Bell PRF.
Endovascular repair of an innominate artery false aneurysm following blunt trauma Journal of Endovascular Surgery 2000; 7(3): 245-50.

30) Loftus IM, Naylor AR, Bell PRF, Thompson MM.
Plasma MMP-9: a marker of plaque instability.
European Journal of Vascular and Endovascular Surgery 2001; 21: 17-21.

31) Loftus IM.A Novel Escape Route for Gallstones
Update 20-06-2001; 870.

32) Turney B, Kent SJS, Loftus IM.
Amputation- the end of the road?
Journal of the Royal College of Surgeons of Edinburgh 2001; 46: 271-273.

33) Loftus IM, Naylor AR, Bell PRF, Thompson MM.
MMPs and atherosclerotic plaque instability (Review Article).
British Journal of Surgery 2002; 89: 680-694.

34) Loftus IM, Thompson MM.
The Role of MMPs in Vascular Disease (Review Article)
Vascular Medicine 2002; 7: 117-133.

35) Axisa B, Loftus IM, Naylor AR, Goodall S, Jones L, Bell PRF and Thompson
MM.
A prospective randomised double blinded trial investigating the effect of doxycycline on matrix metalloproteinase expression within atherosclerotic carotid plaques.
Stroke 2002,33:2858-64.

36) Evans J, Bhardwaj N, Loftus IM, Thompson MM.
Management of intermittent claudication.
British Journal of Surgery 2002: 89; 529-31.

37) Loftus IM, Thompson.
The Abdominal Compartment Syndrome in Vascular Surgery (Review Article).
European Journal of Vascular and Endovascular Surgery 2002: 25; 97-109.

38) Molloy K, Thompson MM, Fishwick G, Bell PRF, Loftus IM.
Endovascular repair of a ruptured aneurysm under local anaesthetic.
European Journal of Vascular and Endovascular Surgery Extra 2003; 5: 3-4.

39) Loftus IM, Molloy KJ, Bell PRF and Naylor AR.
Ruptured Infrarenal Mycotic Aortic Aneurysm (Saved by the Thoracic Coarctation)
Journal of The Royal Society of Medicine 2003; 96: 291-292.

40) Thompson MM, Papavassiliou V, Anderton M, Loftus I, Turner D, Naylor R,
London N, Bell P
The Physiological Effects of Elevated Intra-Abdominal Pressure Following Aneurysm Repair.
European Journal of Vascular and Endovascular Surgery 2003: 26; 293-298.

41) Loftus IM, Bell PRF. Acute Limb Ischaemia- Surgical Options.
Endovascular Today, March 2003; 53-55.

42) Naylor R, Cuffe RL, Rothwell PM, Loftus IM, Bell PRF.
A systematic review of outcome following synchronous carotid endarterectomy and coronary artery bypass: influence of surgical and patient variables.
European Journal of Vascular and Endovascular Surgery 2003: 26; 230-141.

43) Loftus IM, Hayes PD, Bell PRF
The role of subintimal angioplasty: A Review Article
The Journal of Cardiovascular Surgery 2004; 45: 217-229.

44) Molloy KJ, Thompson MM, Jones JL, Schwalbe EC, Bell PRF, Naylor AR,Loftus IM.
Comparison of Levels of Matrix Metalloproteinases, Tissue Inhibitor of Metalloproteinases, Interleukins and Tissue Necrosis Factor in Carotid Endarterectomy Specimens from Patients On – vs – Not On Statins Pre-operatively.
American Journal of Cardiology 2004; 94:144-146.

45) Molloy KJ, Thompson MM, Jones JL, Schwalbe EC, Bell PRF, Naylor AR,Loftus IM.
Elevation in plasma mmp-9 following carotid endarterectomy is associated with particulate cerebral embolisation
European Journal of Vascular and Endovascular Surgery 2004; 27: 409-413.

46) Molloy KJ, Thompson MM, Jones JL, Schwalbe EC, Bell PRF, Naylor AR,Loftus IM.
Unstable Carotid Plaques Exhibit Raised MMP-8 Activity
Circulation 2004; 110: 337-343.

47) Bown MJ, Norwood MG, Loftus IM, Spiers P, Sayers RD.
The SACU: effects on surgical workload and mortality.
ANZ J Surg 2004; 74: 881-4.

48) Squire IB, Evans J, Ng LL, Loftus IM, Thompson MM.
Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction.
J Card Fail. 2004 Aug;10(4):328-33.

49) Rayt HS, Naylor AR, Loftus IM.
'All That Glitters isn't Gold': rupture of an undiagnosed splanchnic aneurysm in the presence of an aortic aneurysm.
Eur J Vasc Endovasc Surg. 2005 Nov;30(5):528-30

50) Choke E, Cockerill G, Wilson WR, Sayed S, Dawson J, Loftus I, Thompson MM.
A review of biological factors implicated in abdominal aortic aneurysm rupture.
Eur J Vasc Endovasc Surg. 2005 Sep;30(3):227-44.
51) Choke E, Thompson MM, Dawson J, Wilson WR, Sayed S, Loftus IM, Cockerill GW.
Abdominal Aortic Aneurysm Rupture Is Associated With Increased Medial Neovascularization and Overexpression of Proangiogenic Cytokines.
Arterioscler Thromb Vasc Biol. 2006 Jun 29

52) Brooks M, Loftus I, Morgan R, Thompson M.
The Valiant thoracic endograft.
J Cardiovasc Surg (Torino). 2006 Jun;47(3):269-78.

53) Dawson J, Choke E, Sayed S, Cockerill G, Loftus I, Thompson MM.
Pharmacotherapy of abdominal aortic aneurysms.
Curr Vasc Pharmacol. 2006 Apr;4(2):129-49. Review

54) Thompson MM, Dawson J, Vig S, Chole E, Blundell J, Horne J, Downham C,Loftus IM.
Medical Optimisation Can Reduce Morbidity And Mortality Associated With Elective Aortic Aneurysm Repair.
Eur J Vasc Endovasc Surg 2006;33(1);100-4.

55) Dawson J, Cockerill G, Choke E, Loftus I, Thompson MM.
Aortic aneurysms as a source of circulating IL-6.
Annals of NY Acad Sci 2006;1085:320-3.

56) Dawson J, Tooze J, Cockerill G, Choke E, Loftus IM, Thompson MM.
Endothelial Progenitor Cells and Abdominal Aortic Aneurysms
Annals of NY Acad Sci 2006;1085:327-30.

57) Choke E, Munneke G, Morgan R, Belli AM, Loftus I, McFarland R, Loosemore, T, Thompson MM.
Outcomes of Endovascular Abdominal Aortic Aneurysm Repair in Patients with Hostile Neck Anatomy.
Cardiovasc Intervent Radiol. 2006;29(6):975-80.

58) Dawson J, Cockerill G, Choke E, Loftus I, Thompson I
Circulating cytokines in patients with abdominal aortic aneurysms.
Ann N Y Acad Sci. 2006 Nov;1085:324-6.

59) Choke E, Cockerill GW, Dawson J, Wilson RW, Jones A, Loftus IM, ThompsonMM.
Increased angiogenesis at the site of abdominal aortic aneurysm rupture.
Ann N Y Acad Sci. 2006 Nov;1085:315-9.

60) Choke E, Thompson MM, Jones A, Torsney E, Dawson J, Laing K, Nasr H,Loftus IM, Cockerill GW.
Gene expression profile of abdominal aortic aneurysm rupture.
Ann N Y Acad Sci. 2006 Nov;1085:311-4

61) Choke E, Cockerill GW, Dawson J, Chung YL, Griffiths J, Wilson RW, LoftusIM, Thompson MM.
Hypoxia at the site of AAA rupture is not associated with increased lactate.
Ann N Y Acad Sci 2006; 1085:306-310.

62) Wilson RW, Choke EC, Dawson J, Loftus IM, Thompson MM.
Contemporary management of the infrarenal aortic aneurysm.
Surgeon 2006;4:363-71.

63) Dawson J, Cockerill GW, Choke E, Belli AM, Loftus IM, Thompson MM.
Aortic aneurysms secrete IL-6 into the circulation.
J Vasc Surg 2007;45(2):350-356.

64) Holt PJ, Poloniecki JD, Loftus IM, Thompson MM.
Meta-Analysis and Systematic Review of the Relationship between Hospital Volume and Outcome Following Carotid Endarterectomy.
Eur J Vasc Endovasc Surg 2007; 33(6): 645-651.

65) Holt PJ, Poloniecki JD, Loftus IM, Thompson MM.
Epidemiological Study of the Relationship between Volume and Outcome after Abdominal Aortic Aneurysm Surgery in the UK from 2000 to 2005.
Br J Surg 2007; 94(4):441-8.

66) Wales L, Howard A, Bohm N, Munneke G, Loftus IM, Thompson MM.
The use of an extra-corporeal graft to maintain cerebral perfusion during
thoracic endovascular aneurysm repair.
Eur J Vasc Endovasc Surg 2007; 34:176-8.

67) Wales L, Nasr H, Bohm N, Howard A, Loftus IM, Thompson MM.
Paediatric venous malformation: treatment with endovenous laser and foam
Sclerotherapy.
Eur J Vasc Endovasc Surg 2007; Extra 14: 6-7.

68) Choke E, Munneke G, Morgan R, Belli AM, Dawson J, Loftus IM, McFarland R,Loosemore T, Thompson MM.
Visceral and Renal Artery Complications of Suprarenal Fixation during Endovascular Aneurysm Repair.
Cardiovasc Intervent Radiol 2007;30(4):619-27.

69) Holt PJ, Poloniecki JD, Gerrard D, Loftus IM, Thompson MM.
Meta-analysis and systematic review of the relationship between volume and outcome in abdominal aortic aneurysm surgery.
Br J Surg 2007 Apr;94(4):395-403.

70) Walkden RM, Morgan RA, Loftus IM, Thompson MM.
Chronic aneurysmal aortic dissection.
Endovascular Today 2007; 6(4):72-75.

71) Holt PJ, Poloniecki JD, Loftus IM, Thompson MM.
Demonstrating safety through in-hospital mortality analysis following elective abdominal aortic aneurysm repair in England.
Br J Surg 2008;95:64-71.

72) Loftus IM, Thompson MM.
The role of carotid stenting: A review.
J Endovasc Ther 2007; Oct 14: 705-11.

73) Evans J, Powell JT, Schwalbe E, Loftus IM, Thompson MM.
Simvastatin Attenuates the Activity of Matrix Metalloprotease-9 in Aneurysmal Aortic Tissue.
Eur J Vasc Endovasc Surg 2007;34(3):302-3.

74) Thompson MM, Ivaz, S, Cheshire N, Fattori R, Rouseeau H, Heijmen R, BeregiJP, Thony F, Horne G, Morgan R, Loftus IM.
Early Results of Endovascular Treatment of the Thoracic Aorta Using the Valiant Endograft.
Cardiovasc Intervent Radiol 2007; 34(6):1130-8.

75) Holt PJ, Poloniecki JD, Loftus IM, Thompson MM.
The Relationship between Hospital Case Volume and Outcome
from Carotid Endartectomy in England from 2000 to 2005.
Eur J Vasc Endovasc Surg. 2007; 34(6):646-54.

76) Thompson MM, Sayer D, Loftus IM, Morgan R.
Endovascular Treatment of Aortic Dissections.
Endovascular Today 2007(Nov, Suppl 1): 11-13.

77) Young EL, Holt PJ, Poloniecki JD, Loftus IM, Thompson MM.
Meta-analysis and systematic review of the relationship between surgeon annual caseload and mortality for elective open abdominal aortic aneurysm repairs.
J Vasc Surg 2007;46:1287-94.

78) Bratby MJ, Munneke GM, Belli AM, Loosemore TM, Loftus I, Thompson MM,Morgan RA.
How safe is bilateral internal iliac artery embolization prior to EVAR?
Cardiovasc Intervent Radiol 2007; 31(2):246-53.

79) Aarvold A, Wales L, Papadakos N, Munneke G, Thompson MM, Loftus IM.
Arterio-ureteric fistula following iliac angioplasty.
CardioVasc Intervent Radiol 2008; 31(4):821-3.

80) Hinchliffe RJ, Halawa M, Holt PJ, Morgan R, Loftus I, Thompson MM.
Aortic dissection and its endovascular management. J Cardiovasc Surg (Torino). 2008 Aug;49(4):449-60.

81) Biasi L, Ali T, Hinchliffe R, Morgan R, Loftus I, Thompson M.
Intraoperative DynaCT Detection and Immediate Correction of a Type 1a Endoleak Following Endovascular Repair of Abdominal Aortic Aneurysm.
Cardiovasc Intervent Radiol. 2008 Jul 26.

82) Loftus I, Thompson M.
Plaque Biology: Interesting Science or Pharmacological Treasure Trove?
Eur J Vasc Endovasc Surg. 2008;36(5):507-16.

83) Papadakos N, Wales L, Hayes K, Belli AM, Loftus I, Ray S.
Post-traumatic pelvic pseudoaneurysm and arterio-venous fistula: combined endovascular and surgical approach.
Eur J Vasc Endovasc Surg. 2008;36(2):164-6.

84) Bohm N, Wales L, Dunckley M, Morgan R, Loftus I, Thompson M.
Objective risk-scoring systems for repair of abdominal aortic aneurysms: applicability in endovascular repair?
Eur J Vasc Endovasc Surg. 2008;36(2):172-7.

85) Wilson WR, Anderton M, Choke EC, Dawson J, Loftus IM, Thompson MM.
Elevated plasma MMP1 and MMP9 are associated with abdominal aortic aneurysm rupture.
Eur J Vasc Endovasc Surg. 2008;35(5):580-4.

86) Walkden RM, Morgan RA, Loftus I, Thompson M.
Treatment of a chronic aneurysmal aortic dissection in a patient with Marfan syndrome using a staged hybrid procedure and a fenestrated endograft.
Cardiovasc Intervent Radiol. 2008;31 Suppl 2:S72-6.

87) Holt PJ, Poloniecki J, Hinchliffe R, Loftus IM, Thompson MM.
A model for the reconfiguration of specialised vascular services.
Br J Surg 2008;95(12):1469-74.

88) Ali T, Biasi L, Hinchliffe R, Morgan R, Thompson MM, Loftus IM.
Atherosclerotic aneurysms. Comparisons between stent grafts- how do we know which one to select?
Acta Chir Belg 2008;108:386-392.

89) Halawa M, Patterson B, Holt P, Thompson MM, Loftus IM.
Comparisons between thoracic stent grafts- how do we know which one to select?
Vascular Disease Management (In Press)

90) Brar R, Ali T, Morgan R, Loftus I, Thompson M.
Endovascular Repair of an Aortic Arch Aneurysm using a Branched Stent Graft.
Eur J Vasc Endovasc Surg. 2008;36(5):545-9.

91) Sayer D, Bratby M, Brooks M, Loftus I, Morgan R, Thompson M.
Aortic morphology Following Endovascular Repair of Acute and Chronic Type B Aortic Dissection: Implications for Management
Eur J Vasc Endovasc Surg. 2008;36(5):522-9.

92) Ali T, Loftus IM.
'Dissections of the thoracic aorta and evolving endovascular strategies'
Cardiovascular & Hematological Disorders - Drug Targets (In Press)

93) Biasi L, Ali T, Ratnam LA, Morgan R, Loftus I, Thompson M.
Intra-operative DynaCT improves technical success of endovascular repair of abdominal aortic aneurysms.
J Vasc Surg. 2009;49(2):288-95.

94) Dawson JA, Choke E, Cockerill GW, Loftus IM, Thompson MM.
The long-term effects of open and endovascular aneurysm repair on circulating interleukin-6.
Eur J Vasc Endovasc Surg. 2009;37(1):43-5.

95) Patterson BO, Holt PJ, Hinchliffe R, Loftus IM, Thompson MM.
Predicting risk in elective abdominal aortic aneurysm repair: a systematic review of current evidence.
Eur J Vasc Endovasc Surg. 2008;36(6):637-45.

96) Wilson WR, Choke EC, Dawson J, Loftus IM, Thompson MM.
Plasma MMP levels do not predict tissue levels in abdominal aortic aneurysms suitable for elective repair.
Vascular 2008;16:248-52.

97) Choke E, Cockerill GW, Laing K, Dawson J, Wilson WR, Loftus IM, ThompsonMM.
Whole genome expression profiling reveals a role for immune and inflammatory response in abdominal aortic aneurysm rupture.
Eur J Vasc Endovasc Surg 2008 Dec 24 (epub ahead of print)

98) Biasi L, Ali T, Ratnam LA, Morgan R, Loftus I, Thompson MM.
A multicentre randomised trial of cryo stripping versus conventional stripping of the great saphenous vein.
J Vasc Surg 2009;49(2):288-95.

99) Ali T, Sayers D, Thompson MM, Loftus IM.
Dissections of the thoracic aorta and evolving endovascular strategies.
Current Hypertension Reviews (in press)

100) Sayed S, Cockerill GW, Torsney E, Poston R, Thompson MM, Loftus IM.
Elevated expression of thrombomodulatory factors correlates with acute symptomatic carotid plaque phenotype.
Eur J Vasc Endovasc Surg (in press)